Identification of s-Regulated Genes in Salmonella typhimurium: Complementary Regulatory Interactions between s and Cyclic AMP Receptor Protein
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Intracellular cyclic AMP concentration is decreased in Salmonella typhimurium fur mutants.
It is known that the Fur protein negatively regulates iron-uptake systems in different bacterial species, including Salmonella typhimurium. In this study it has been shown that the intracellular concentration of cyclic AMP (cAMP) is lower in a knockout S. typhimurium fur mutant than in the wild-type strain. According to this, the expression of two cAMP-regulated genes, such as pepE (encoding an...
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Mutants deficient in orotate utilization (initially termed out mutants) were isolated by selection for resistance to 5-fluoroorotate (FOA), and the mutations of 12 independently obtained isolates were found to map at 79 to 80 min on the Salmonella typhimurium chromosome. A gene complementing the mutations was cloned and sequenced and found to possess extensive sequence identity to characterized...
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A water snake (Natrix natrix) was referred to the Small Animal Teaching Hospital, Faculty of Veterinary Medicine, University of Tehran. It had two subcutaneous masses. Radiographic and ultrasonographic images revealed the presence of two subcutaneous abscesses. The abscesses were removed surgically and specimens were examined by conventional microbial culture and multiplex PCR. Inv-A universal ...
متن کاملCyclic AMP receptor protein and TyrR are required for acid pH and anaerobic induction of hyaB and aniC in Salmonella typhimurium.
Two acid-inducible genes, aniC and aciK, that require anaerobiosis and tyrosine for expression were identified as orf326a encoding a potential amino acid/polyamine antiporter and hyaB encoding hydrogenase I, respectively. Cyclic AMP (cAMP) receptor protein, cAMP, and TyrR, regulator of aromatic amino acid metabolism, were strong positive regulators of both genes.
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Introduction: In Iran, invasive nontyphoidal Salmonella (iNTS) disease causes severe bacteremic illness among children <5 years old. The global yearly incidence of iNTS disease in children was reported to be in the 3.4 (range 2.1-6.5) million cases, (overall incidence 49 cases (range 30-94) per 100,000 population), the iNTS case-fatality ratio (CFR) of 20% yielded 681,316 deat...
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تاریخ انتشار 1996